| 8000 |
Microfat - Orthopedics |
Intra Articular Injection of Autologous Microfat and Platelets-Rich Plasma in the Treatment of Wrist Osteoarthritis: A P...
|
September 29, 2022; Journal of Clinical Medicine; Alice Mayoly, Marie Witters, Elisabeth Jouve, Cécilia Bec, Aurélie Iniesta, Najib Kachouh, Julie ... |
Emergence of biotherapies based on adipose derived stem cells (ADSC) offers promising treatments for chondral degenerative diseases. Microfat (MF) and platelets-rich plasma (PRP) mixture, rich in grow... |
Journal of Clinical Medicine |
Alice Mayoly, Marie Witters, Elisabeth Jouve, Cécilia Bec, Aurélie Iniesta, Najib Kachouh, Julie Veran, Fanny Grimaud, Anouck Coulange Zavarro, Rémi Fernandez, David Bendahan, Laurent Giraudo, Chloé Dumoulin, Christophe Chagnaud, Dominique Casanova, Florence Sabatier, Régis Legré, Charlotte Jaloux,and Jérémy Magalon |
2022-09-29 |
| 8000 |
Microfat - Orthopedics |
Subchondral versus intra-articular orthobiologic injections for the treatment of knee osteoarthritis: a review
|
April 12, 2022; Regenerative Medicine; James E Gardner, Christopher W Williams, Robert L Bowers |
This review highlights the rationale and current evidence for intra-articular and subchondral bone injections of orthobiologics for the treatment of OA. |
Regenerative Medicine |
James E Gardner, Christopher W Williams, Robert L Bowers |
2022-04-12 |
| 8000 |
Microfat - Orthopedics |
Stromal Vascular Fraction for Knee Osteoarthritis – An Update
|
April 05, 2022; Journal of Stem Cells and Regenerative Medicine; José Fábio Santos Duarte Lana, Anna Vitória Santos Duarte Lana, Lucas Furtado da Fonseca, Marcelo... |
Stromal vascular fraction obtained from processed adipose tissue may be presented as an excellent orthobiologic tool for the treatment of many complicated and impactful musculoskeletal disorders, such... |
Journal of Stem Cells and Regenerative Medicine |
José Fábio Santos Duarte Lana, Anna Vitória Santos Duarte Lana, Lucas Furtado da Fonseca, Marcelo Amaral Coelho, Guilherme Gabriel Marques, Tomas Mosaner, Lucas Leite Ribeiro, Gabriel Ohana Marques Azzini, Gabriel Silva Santos, Eduardo Fonseca, Marco Antonio Percope de Andrade |
2022-04-05 |
| 8000 |
Microfat - Orthopedics |
Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA...
|
September 14, 2022; Knee Surgery, Sports Traumatology, Arthroscopy; Carlotta Perucca Orfei, Angelo Boffa,Yosef Sourugeon, Lior Laver, Jérémy Magalon, Mikel Sánchez, ... |
The aim of this systematic review was to determine if adipose tissue-derived cell-based injectable therapies can induce disease-modifying effects in joints affected by osteoarthritis (OA). |
Knee Surgery, Sports Traumatology, Arthroscopy |
Carlotta Perucca Orfei, Angelo Boffa,Yosef Sourugeon, Lior Laver, Jérémy Magalon, Mikel Sánchez, Thomas Tischer, Giuseppe Filardo, and Laura de Girolamo |
2022-09-14 |
| 8010 |
Wound Healing |
Microfat exerts an anti-fibrotic effect on human hypertrophic scar via fetuin-A/ETV4 axis
|
March 31, 2023; Journal of Translational Medicine; Qian Yu, Qiang Dai, Zonglin Huang, Chen Li, Li Yan, Xin Fu, Qian Wang, Yi Zhang, Lei Cai, Zhigang Ya... |
Hypertrophic scar is a fibrotic disease following wound healing and is characterized by excessive extracellular matrix deposition. Autologous microfat grafting proves an effective strategy for the tre... |
Journal of Translational Medicine |
Qian Yu, Qiang Dai, Zonglin Huang, Chen Li, Li Yan, Xin Fu, Qian Wang, Yi Zhang, Lei Cai, Zhigang Yang, and Ran Xiao |
2023-03-31 |
| 8975 |
Microfat - Orthopedics |
Cell-Based Therapies for Rotator Cuff Injuries: An Updated Review of the Literature
|
March 08, 2024; International Journal of Molecular Sciences; Nicholas Hooper, Anuj Marathe, Nitin B. Jain, and Prathap Jayaram |
This review focuses on non-surgical treatment options for rotator cuff injuries and highlights the potential of mesenchymal stem cells (MSCs) as a potential regenerative approach. |
International Journal of Molecular Sciences |
Nicholas Hooper, Anuj Marathe, Nitin B. Jain, and Prathap Jayaram |
2024-03-08 |
| 8935 |
Microfat - Aesthetics |
Protein Profiling of Mechanically Processed Lipoaspirates: Discovering Wound Healing and Antifibrotic Biomarkers in Nano...
|
June 06, 2022; Plastic and Reconstructive Surgery; Nadia Sanchez-Macedo, Ph.D., Michelle McLuckie, Ph.D.,Lisanne Grünherz, M.D.,and Nicole Lindenblatt... |
This study shows that the effects of microfat and nanofat treatment are based on up-regulated inflammation, antimicrobial, and wound healing pathways. Mechanical emulsification does not alter the conc... |
Plastic and Reconstructive Surgery |
Nadia Sanchez-Macedo, Ph.D., Michelle McLuckie, Ph.D.,Lisanne Grünherz, M.D.,and Nicole Lindenblatt, M.D. |
2022-06-06 |
| 8000 |
Microfat - Orthopedics |
Autologous Microfragmented Adipose Tissue for the Treatment of Knee Osteoarthritis: Real-World Data at Two Years Follow-...
|
February 25, 2022; Journal of Clinical Medicine; Daniele Screpis, Simone Natali, Luca Farinelli, Gianluca Piovan, Venanzio Iacono, Laura de Girolamo,... |
The purpose of the present study was to assess, prospectively, the safety, clinical effectiveness, and feasibility of a single intra-articular injection of microfragmented adipose tissue in different ... |
Journal of Clinical Medicine |
Daniele Screpis, Simone Natali, Luca Farinelli, Gianluca Piovan, Venanzio Iacono, Laura de Girolamo, Marco Viganò, and Claudio Zorzi |
2022-02-25 |
| 8940 |
Microfat - Orthopedics |
Efficacy and Long-Term Outcomes of Intra-Articular Autologous Micro-Fragmented Adipose Tissue in Individuals with Glenoh...
|
August 26, 2023; Journal of Personalized Medicine; Simone Natali, Daniele Screpis, Edoardo Patania, Luca De Berardinis, Andrea Benoni, Gianluca Piovan,... |
The aim of this retrospective study was to report the safety and clinical outcomes of intra-articular injection of ADMSCs in patients with GOA over 36-months. |
Journal of Personalized Medicine |
Simone Natali, Daniele Screpis, Edoardo Patania, Luca De Berardinis, Andrea Benoni, Gianluca Piovan, Venanzio Iacono,Bruno Magnan,Antonio Pompilio Gigante, and Claudio Zorzi |
2023-08-26 |
| 10010 |
Microfat - Orthopedics |
Clinical Evaluation of Safety and Efficacy of a Central Current Good Manufacturing Practices Laboratory Produced Autolog...
|
April 03, 2024; Stem Cells and Development; Christopher J Rogers, Robert Harman, Mitchell B Sheinkop, Peter Hanson, Mary A Ambach, Tal David, R... |
A single-arm, open-label, multisite, FDA approved clinical study in Kellgren-Lawrence severity grade 2-4 KOA patients. The cellular product was manufactured from patient-specific lipoaspirate in a cen... |
Stem Cells and Development |
Christopher J Rogers, Robert Harman, Mitchell B Sheinkop, Peter Hanson, Mary A Ambach, Tal David, Rahul Desai, Steven Sampson, Danielle Aufierro, Jay Bowen, Gerard Malanga |
2024-04-03 |
| 7770 |
Microfat - Orthopedics |
Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor P...
|
December 26, 2022; MDPI - Journal of Persoanlized medicine - Volume 13 Issue 1 ; Vilim Molnar, Eduard Pavelić, Željko Jeleč, Petar Brlek, Vid Matišić, Igor Borić, Damir Hudetz... |
The aim of this study was to evaluate clinical and radiological findings after the application of autologous conditioned adipose tissue (ACA) and leukocyte-poor PRP (LP-PRP) in patients with mild to m... |
MDPI - Journal of Persoanlized medicine - Volume 13 Issue 1 |
Vilim Molnar, Eduard Pavelić, Željko Jeleč, Petar Brlek, Vid Matišić, Igor Borić, Damir Hudetz, Eduard Rod, Dinko Vidović, Neven Starčević, Martin Čemerin, David C. Karli, and Dragan Primorac |
2022-12-26 |
| 6005 |
Wound Healing |
Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds
|
February 16, 2016; Taylor and Francis online; Giovanni Marfia, Stefania Elena Navone, Clara Di Vito, Nicola Ughi, Silvia Tabano, Monica Miozzo, Ca... |
In this study, we report that microfragmented human lipoaspirated adipose tissue is a better stem cell source compared to normal lipoaspirated tissue. The structural composition of microfragments is c... |
Taylor and Francis online |
Giovanni Marfia, Stefania Elena Navone, Clara Di Vito, Nicola Ughi, Silvia Tabano, Monica Miozzo, Carlo Tremolada, Gianni Bolla, Chiara Crotti, Francesca Ingegnoli, Paolo Rampini, Laura Riboni, Roberta Gualtierotti, and Rolando Campanella |
2016-02-16 |
| 6965 |
Science/Research |
Characteristics and Properties of Mesenchymal Stem Cells Derived From Microfragmented Adipose Tissue
|
May 14, 2014; National Library of Medicine; Stephana Carelli, Fanuel Messaggio, Alessandra Canazza, Danuta Maria Hebda, Filippo Caremoli, Elisa ... |
In this study, we report that microfragmented human lipoaspirated adipose tissue is a better stem cell source compared to normal lipoaspirated tissue. The structural composition of microfragments is c... |
National Library of Medicine |
Stephana Carelli, Fanuel Messaggio, Alessandra Canazza, Danuta Maria Hebda, Filippo Caremoli, Elisa Latorre, Maria Grazia Grimoldi, Mattia Colli, Gaetano Bulfamante, Carlo Tremolada, Anna Maria Di Giulio, Alfredo Gorio |
2014-05-14 |
| 6985 |
Science/Research |
Human Lipoaspirate as Autologous Injectable Active Scaffold for One-Step Repair of Cartilage Defects
|
June 01, 2016; Sage Journals - Cell Transplantation; Michela Bosetti, Ph.D., Alessia Borrone, Antonia Follenzi, Fanuel Messaggio, Carlo Tremolada, and Ma... |
Research on mesenchymal stem cells from adipose tissue shows promising results for cell-based therapy in cartilage lesions. In these studies, cells have been isolated, expanded, & differentiated i... |
Sage Journals - Cell Transplantation |
Michela Bosetti, Ph.D., Alessia Borrone, Antonia Follenzi, Fanuel Messaggio, Carlo Tremolada, and Mario Cannas |
2016-06-01 |
| 5635 |
Science/Research |
Arthroscopic treatment of chondral defects in the hip: AMIC, MACI, microfragmented adipose tissue transplantation (MATT)...
|
June 07, 2017; SICOT-J Volume 3; Eugenio Jannelli and Andrea Fontana |
Microfragmented adipose tissue transplantation (MATT) is indicated for the treatment of delamination & 1st and 2nd degree chondral lesions, regardless of the age of the patient. Chondral defects a... |
SICOT-J Volume 3 |
Eugenio Jannelli and Andrea Fontana |
2017-06-07 |
| 5420 |
Science/Research |
Adipose-Derived Stem Cell Transplant Technique for Degenerative Joint Disease
|
October 02, 2017; Arthroscopy Techniques - VOLUME 6, ISSUE 5, E1761-E1766; Ryan P Coughlin, Alexander Oldweiler, Dayne T Mickelson, and laude T Moorman 3rd |
The treatment of mild to moderate osteoarthritis can be a challenging problem for orthopaedic surgeons. As new research & treatment strategies have emerged, stem cell therapy has risen in populari... |
Arthroscopy Techniques - VOLUME 6, ISSUE 5, E1761-E1766 |
Ryan P Coughlin, Alexander Oldweiler, Dayne T Mickelson, and laude T Moorman 3rd |
2017-10-02 |
| 6790 |
Science/Research |
Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Sa...
|
July 23, 2018; Stem Cells Translational Medicine, Volume 7, Issue 11; Offer Zeira, Simone Scaccia, Letizia Pettinari, Erica Ghezzi, Nimrod Asiag, Laura Martinelli, Daniel... |
The procedure is time-sparing & cost-effective. Post-injection cytological investigation, together with the clinical evidence, suggests a long-term pain control role of this treatment. |
Stem Cells Translational Medicine, Volume 7, Issue 11 |
Offer Zeira, Simone Scaccia, Letizia Pettinari, Erica Ghezzi, Nimrod Asiag, Laura Martinelli, Daniele Zahirpour, Maria P Dumas, Martin Konar, Davide M Lupi, Laurence Fiette, Luisa Pascucci, Leonardo Leonardi, Alistair Cliff, Giulio Alessandri, Augusto Pessina, Daniele Spaziante, and Marina Aralla |
2018-07-23 |
| 5760 |
Microfat - Orthopedics |
Autologous micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis: an update at 3...
|
December 19, 2018; Journal of Experimental Orthopaedics - 2018 Dec 19;5(1):52.; A. Russo, D. Screpis, S. L. Di Donato, S. Bonetti, G. Piovan & C. Zorzi |
The results point to autologous & micro-fragmented adipose tissue injection as an innovative & safe approach for the management of diffuse degenerative knee chondropathy in the mid-term. The p... |
Journal of Experimental Orthopaedics - 2018 Dec 19;5(1):52. |
A. Russo, D. Screpis, S. L. Di Donato, S. Bonetti, G. Piovan & C. Zorzi |
2018-12-19 |
| 5800 |
Microfat - Orthopedics |
Preliminary results of autologous adipose-derived stem cells in early knee osteoarthritis: identification of a subpopula...
|
October 03, 2018; International Orthopaedics - 2019 Jan;43(1):7-13; Alfredo Schiavone Panni, Michele Vasso, Adriano Braile, Giuseppe Toro, Annalisa De Cicco, Davide Vig... |
The knee injection of aASCs associated to arthroscopic debridement increased significantly the clinical and functional scores in patients with early KOA at a mid-term follow-up, especially those with ... |
International Orthopaedics - 2019 Jan;43(1):7-13 |
Alfredo Schiavone Panni, Michele Vasso, Adriano Braile, Giuseppe Toro, Annalisa De Cicco, Davide Viggiano and, Federica Lepore |
2018-10-03 |
| 7775 |
Microfat - Orthopedics |
Microfragmented adipose injections in the treatment of knee osteoarthritis
|
October 18, 2018; Journal of Clinical Orthopaedics and Trauma - VOLUME 10, ISSUE 1, P46-48; Gerard A. Malanga, Sean Bemanian |
The field of regenerative medicine provides a new area of nonoperative treatment to address various orthopedic conditions including knee osteoarthritis. The potential for improvement of a patient̵... |
Journal of Clinical Orthopaedics and Trauma - VOLUME 10, ISSUE 1, P46-48 |
Gerard A. Malanga, Sean Bemanian |
2018-10-18 |
| 5885 |
Microfat - Orthopedics |
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
|
January 23, 2018; JoVE Journal; Riccardo D'Ambrosi, Cristian Indino, Camilla Maccario, Luigi Manzi, and Federico Giuseppe Usuelli |
In recent years, regenerative techniques have been increasingly studied & used to treat osteochondral lesions of the talus. In particular, several studies have focused their attention on mesenchym... |
JoVE Journal |
Riccardo D'Ambrosi, Cristian Indino, Camilla Maccario, Luigi Manzi, and Federico Giuseppe Usuelli |
2018-01-23 |
| 6755 |
Microfat - Orthopedics |
Micro-fragmented adipose tissue injection associated with arthroscopic procedures in patients with symptomatic knee oste...
|
May 30, 2018; BMC Musculoskeletal Disorders volume 19, Article number: 176 (2018) ; G Cattaneo, A De Caro, F Napoli, D Chiapale, P Trada, and A Camera |
The result of the study pointed to micro-fragmented adipose tissue as a safe and beneficial adjuvant in the surgical treatment of degenerative knee chondropathy. A longer follow-up is needed to draw d... |
BMC Musculoskeletal Disorders volume 19, Article number: 176 (2018) |
G Cattaneo, A De Caro, F Napoli, D Chiapale, P Trada, and A Camera |
2018-05-30 |
| 5455 |
Microfat |
Micro-fragmented adipose tissue injection for the treatment of complex anal fistula: a pilot study accessing safety and ...
|
February 16, 2018; Techniques in Coloproctology - 22, pages107–113 (2018); G Naldini, A Sturiale, B Fabiani, I Giani, and C Menconi |
The injection of autologous, micro-fragmented & minimally manipulated adipose tissue associated with closure of the internal opening is a safe, feasible & reproducible procedure & may enha... |
Techniques in Coloproctology - 22, pages107–113 (2018) |
G Naldini, A Sturiale, B Fabiani, I Giani, and C Menconi |
2018-02-16 |
| 6980 |
Microfat - Orthopedics |
Effect of microfragmented adipose tissue on osteoarthritic synovial macrophage factors
|
June 09, 2019; Journal of Celluar Physiology - ORIGINAL RESEARCH ARTICLE; Francesca Paolella, Cristina Manferdini, Elena Gabusi, Laura Gambari, Giuseppe Filardo, Elizaveta Ko... |
Cell-based therapies using adipose-derived mesenchymal stromal cells (ADMSCs) have shown promising results for the treatment of osteoarthritis (OA). |
Journal of Celluar Physiology - ORIGINAL RESEARCH ARTICLE |
Francesca Paolella, Cristina Manferdini, Elena Gabusi, Laura Gambari, Giuseppe Filardo, Elizaveta Kon, Erminia Mariani, and Gina Lisignoli |
2019-06-09 |
| 5680 |
Diseases |
Micro-fragmented fat injection reduces sepsis-induced acute inflammatory response in a mouse model
|
May 22, 2018; British Journal Anaethesia - VOLUME 121, ISSUE 6, P1249-1259, ; A Bouglé, P Rocheteau, M Hivelin, A Haroche, D Briand, C Tremolada, J Mantz, and F Chrétien |
In a murine model of severe sepsis, micro-fragmented fat improved early inflammatory status and outcome, at least in part, by a cyclo-oxygenase-2-mediated mechanism. |
British Journal Anaethesia - VOLUME 121, ISSUE 6, P1249-1259, |
A Bouglé, P Rocheteau, M Hivelin, A Haroche, D Briand, C Tremolada, J Mantz, and F Chrétien |
2018-05-22 |
| 7740 |
Microfat - Orthopedics |
Immunophenotyping of a Stromal Vascular Fraction from Microfragmented Lipoaspirate Used in Osteoarthritis Cartilage Trea...
|
June 21, 2019; MDPI Volume 10 Issue 6 ; Denis Polancec, Lucija Zenic, Damir Hudetz, Igor Boric, Zeljko Jelec, Eduard Rod, Trpimir Vrdoljak, ... |
Osteoarthritis (OA) is a degenerative joint disease accompanied by pain and loss of function. The role of EP in pericyte-primed MSC-mediated tissue healing, as well as the observed hormonal implicatio... |
MDPI Volume 10 Issue 6 |
Denis Polancec, Lucija Zenic, Damir Hudetz, Igor Boric, Zeljko Jelec, Eduard Rod, Trpimir Vrdoljak, Andrea Skelin, Mihovil Plecko, Mirjana Turkalj, Boro Nogalo and Dragan Primorac |
2019-06-21 |
| 6660 |
Science/Research |
Regenerative Features of Adipose Tissue for Osteoarthritis Treatment in a Rabbit Model: Enzymatic Digestion Versus Mecha...
|
May 29, 2019; MDPI Volume 20 Issue 11; Giovanna Desando, Isabella Bartolotti, Lucia Martini, Gianluca Giavaresi, Nicolò Nicoli Aldini, Mil... |
This research explores migrating expanded-adipose stromal cells & adipose niches after enzymatic & mechanical processes. Bilateral anterior cruciate ligament transection induced a mild grade o... |
MDPI Volume 20 Issue 11 |
Giovanna Desando, Isabella Bartolotti, Lucia Martini, Gianluca Giavaresi, Nicolò Nicoli Aldini, Milena Fini, Alice Roffi, Francesco Perdisa, Giuseppe Filardo, Elizaveta Kon, Brunella Grigolo |
2019-05-29 |
| 5575 |
Science/Research |
Microfragmented human fat tissue is a natural scaffold for drug delivery: Potential application in cancer chemotherapy
|
May 28, 2019; Journal of Controlled Release Volume 302; Giulio Alessandri, Valentina Coccè, Fabio Pastorino, Rita Paroni, Michele Dei Cas, Francesco Restel... |
In an orthotopic mice model of Neuroblastoma (NB) transplant, DMFAT loaded with PTX prevents or delays NB relapse when placed in the surgical area of tumor resection, without any collateral toxicity. ... |
Journal of Controlled Release Volume 302 |
Giulio Alessandri, Valentina Coccè, Fabio Pastorino, Rita Paroni, Michele Dei Cas, Francesco Restelli, Bianca Pollo, Laura Gatti, Carlo Tremolada, Angiola Berenzi, Eugenio Parati, Anna Teresa Brini, Gianpietro Bondiolotti, Mirco Ponzoni, Augusto Pessina |
2019-05-28 |
| 7715 |
Science/Research |
Micro-fragmented stromal-vascular fraction plus microfractures provides better clinical results than microfractures alon...
|
July 11, 2019; Knee Surgery, Sports Traumatology, Arthroscopy volume 28, pages1876–1884; Salvatore Bisicchia, Gabriele Bernardi, Susanna M. Pagnotta, and Cosimo Tudisco |
Injection of micro-fragmented stromal-vascular fraction is safe &, when associated with microfractures, is more effective in clinical terms than microfractures alone in patients affected by sympto... |
Knee Surgery, Sports Traumatology, Arthroscopy volume 28, pages1876–1884 |
Salvatore Bisicchia, Gabriele Bernardi, Susanna M. Pagnotta, and Cosimo Tudisco |
2019-07-11 |
| 5665 |
Science/Research |
The Effect of Intra-articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients w...
|
March 2020; Bioprinting Volume 17, March 2020; Karin Säljö a, Linnéa Stridh Orrhult, Peter Apelgren, Kajsa Markstedt, Lars Kölby, and Paul Gate... |
The results of this study indicate that the use of autologous and microfragmented adipose tissue in patients with knee OA increased glycosaminoglycan content in hyaline cartilage, which is in line wit... |
Bioprinting Volume 17, March 2020 |
Karin Säljö a, Linnéa Stridh Orrhult, Peter Apelgren, Kajsa Markstedt, Lars Kölby, and Paul Gatenholm |
2020-03-01 |
| 6750 |
Science/Research |
Successful engraftment, vascularization, and In vivo survival of 3D-bioprinted human lipoaspirate-derived adipose tiss...
|
March 01, 2020; Bioprinting Volume 17, March 2020; Karin Säljö a, Linnéa Stridh Orrhult, Peter Apelgren, Kajsa Markstedt, Lars Kölby, and Paul Gate... |
Histologic and immunohistochemical characterisation confirmed the presence of potential ASCs during the first week in vivo. These results demonstrated that human lipoaspirate-derived adipose tissue sh... |
Bioprinting Volume 17, March 2020 |
Karin Säljö a, Linnéa Stridh Orrhult, Peter Apelgren, Kajsa Markstedt, Lars Kölby, and Paul Gatenholm |
2020-03-01 |
| 6335 |
Microfat - Orthopedics |
Autologous microfragmented adipose tissue reduces inflammatory and catabolic markers in supraspinatus tendon cells deriv...
|
July 08, 2020; International Orthopaedics 45, pages419–426 (2021); Marco Viganò, Gaia Lugano, Carlotta Perucca Orfei, Alessandra Menon, Enrico Ragni, Alessandra Colom... |
μFAT exerted an anti-inflammatory action on supraspinatus tendon cells in vitro through paracrine action, resulting in the reduction of catabolic & inflammatory marker expression. These observati... |
International Orthopaedics 45, pages419–426 (2021) |
Marco Viganò, Gaia Lugano, Carlotta Perucca Orfei, Alessandra Menon, Enrico Ragni, Alessandra Colombini, Paola De Luca, Pietro Randelli & Laura de Girolamo |
2020-07-08 |
| 7330 |
Microfat - Orthopedics |
Autologous Adipose Orthobiologic Cell Therapy Harvest Technique
|
December 2020; Operative Techniques in Sports Medicine. Volume 28, Issue 4; Joanne Halbrecht MD, Miles Graivier MD |
Patient assessment for adipose deposits & optimal harvest site as well as instrumentation, tissue preparation techniques, & variabilities in recommended volumes are also discussed. Harvest sit... |
Operative Techniques in Sports Medicine. Volume 28, Issue 4 |
Joanne Halbrecht MD, Miles Graivier MD |
2020-12-01 |
| 5515 |
Microfat - Orthopedics |
Chemical Profile and Clinical Efficacy of Micro-Fragmented Adipose Tissue in the Treatment of Knee Osteoarthritis
|
June 23, 2021; Biologic Ortho - Vol. 2 No. 1 (2020): Bio Ortho J ; Jack Haberl, Nathan Hogaboom, Gerard Malanga |
Intra-articular injections of adipose-derived mesenchymal stromal cells (AD-MSCs) have emerged as a regenerative therapy to combat the progression of knee osteoarthritis (OA). |
Biologic Ortho - Vol. 2 No. 1 (2020): Bio Ortho J |
Jack Haberl, Nathan Hogaboom, Gerard Malanga |
2021-06-23 |
| 6580 |
Microfat - Orthopedics |
Mesenchymal stem cells in orthopedics – a current perspective
|
January 2021; Primorac, Engineering Power, Vol. 16(1) 2021; Dragan Primorac, Vid Matišić, Vilim Molnar, Vitorio Perić, Marina Dasović |
MSCs therapy provides a possibly great alternative and it is assumed that it will take a major role in future OA treatment, especially in patients that are not yet candidates for joint replacement sur... |
Primorac, Engineering Power, Vol. 16(1) 2021 |
Dragan Primorac, Vid Matišić, Vilim Molnar, Vitorio Perić, Marina Dasović |
2021-01-01 |
| 5510 |
Microfat - Orthopedics |
Micro-fragmentation is a valid alternative to cell expansion and enzymatic digestion of adipose tissue for the treatment...
|
January 19, 2021; Knee Surgery, Sports Traumatology, Arthroscopy; Giuseppe Filardo, Matilde Tschon, Francesco Perdisa, Silvia Brogini, Carola Cavallo, Giovanna Desand... |
Among the different methods used to exploit the adipose tissue potential, MF showed the most promising findings in particular in terms of protection of the articular surface from the joint degenerativ... |
Knee Surgery, Sports Traumatology, Arthroscopy |
Giuseppe Filardo, Matilde Tschon, Francesco Perdisa, Silvia Brogini, Carola Cavallo, Giovanna Desando, Gianluca Giavaresi, Brunella Grigolo, Lucia Martini, Nicolò Nicoli Aldini, Alice Roffi, Milena Fini & Elizaveta Kon |
2021-01-19 |
| 6695 |
Science/Research |
Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Obs...
|
February 26, 2021; Stem Cell International - Volume 2021 | Article ID 6648437; Tiffanie-Marie Borg, Nima Heidari, Ali Noorani, Mark Slevin, Angela Cullen, Stefano Olgiati, Alberto... |
Identification of the difference between men & women in the response to biologics is new & has not been previously reported. Future studies should use similar protocols to identify gender bias... |
Stem Cell International - Volume 2021 | Article ID 6648437 |
Tiffanie-Marie Borg, Nima Heidari, Ali Noorani, Mark Slevin, Angela Cullen, Stefano Olgiati, Alberto Zerbi, Alessandro Danovi, and Adrian Wilson |
2021-02-26 |
| 6670 |
Microfat - Orthopedics |
Two-year clinical outcomes of autologous microfragmented adipose tissue in elderly patients with knee osteoarthritis: a ...
|
March 02, 2021; International Orthopaedics volume 45, pages1179–1188 (2021); Alberto Gobbi, Ignacio Dallo, Christopher Rogers, Richard D. Striano, K. Mautner, Robert Bowers, Mic... |
This study shows that a single-dose MFAT injection leads to clinical, functional, & quality of life improvement at 2 years in elderly patients, in KL grades 2 to 4 of knee osteoarthritis. These fi... |
International Orthopaedics volume 45, pages1179–1188 (2021) |
Alberto Gobbi, Ignacio Dallo, Christopher Rogers, Richard D. Striano, K. Mautner, Robert Bowers, Michael Rozak, Norma Bilbool & William D. Murrell |
2021-03-02 |
| 5550 |
Science/Research |
Treatment of knee osteoarthritis by intra-articular injection of concentrated autologous adipose tissue: a twenty four ...
|
January 04, 2021; International Orthopaedics volume 45, pages627–633 (2021); Alessandro Bistolfi, Ilaria Roato, Giulia Fornelli, Luigi Sabatini, Alessandro Massè & Riccardo Fer... |
In patients with knee OA, a single intra-articular injection of autologous adipose tissue reduced knee pain, stiffness, improved knee function & quality of life without severe complications. |
International Orthopaedics volume 45, pages627–633 (2021) |
Alessandro Bistolfi, Ilaria Roato, Giulia Fornelli, Luigi Sabatini, Alessandro Massè & Riccardo Ferracini |
2021-01-04 |
| 7750 |
Science/Research |
A 12-Month Cohort Study to Investigate Changes in Patient-Reported Outcomes after Intra-articular Injection of Micro-Fra...
|
June 02, 2021; Biologic Orthopedic Journal, Vol 2(1): e19–e28; Nathan S Hogaboom, PhD, Ella D’Amico, MD, Ken Mautner, MD, Christopher J Rogers, MD, Gerard A Mala... |
A single injection of MFAT improved pain, function, and QOL outcome measures up to 12 months in this cohort for more than half of the participants. Greater BMI and lower age negatively influenced outc... |
Biologic Orthopedic Journal, Vol 2(1): e19–e28 |
Nathan S Hogaboom, PhD, Ella D’Amico, MD, Ken Mautner, MD, Christopher J Rogers, MD, Gerard A Malanga, MD |
2021-06-02 |
| 7220 |
Science/Research |
The use of intra-articular injection of autologous micro-fragmented adipose tissue as pain treatment for ankle osteoarth...
|
June 17, 2021; International Orthopaedics - 45, pages2239–2244 (2021); Simone Natali, Daniele Screpis, Luca Farinelli, Venanzio Iacono, Vittorio Vacca, Antonio Gigante & C... |
The autologous micro-fragmented adipose tissue for the treatment of pain in ankle osteoarthritis is able to provide positive clinical outcomes, potentially offering a minimally invasive therapeutic op... |
International Orthopaedics - 45, pages2239–2244 (2021) |
Simone Natali, Daniele Screpis, Luca Farinelli, Venanzio Iacono, Vittorio Vacca, Antonio Gigante & Claudio Zorzi |
2021-06-17 |
| 6970 |
Science/Research |
A Prospective Study Comparing Leukocyte-Poor Platelet-Rich Plasma Combined with Hyaluronic Acid and Autologous Microfrag...
|
June 29, 2021; Stem Cells and Development VOL. 30, NO. 13 | Original Research Reports; Ignacio Dallo, Dawid Szwedowski, Ali Mobasheri, Eleonora Irlandini, and Alberto Gobbi |
AMAT showed better clinical results in Tegner and KOOS symptoms at 6 months and Tegner at 12 months. Understanding which therapy offers the most benefits with the least risk can significantly improve ... |
Stem Cells and Development VOL. 30, NO. 13 | Original Research Reports |
Ignacio Dallo, Dawid Szwedowski, Ali Mobasheri, Eleonora Irlandini, and Alberto Gobbi |
2021-06-29 |
| 7110 |
Wound Healing |
Health-related quality of life outcomes and hospitalization length of stay after micro-fragmented autologous adipose tis...
|
December 01, 2021; International Angiology : a Journal of the International Union of Angiology; Gennai, Leone, Covic, Migliari, Lonardi, Silingardi |
The MiFrAADiF Trial demonstrated a significant improvement in terms of physical HRQoL & a significant reduction of the hospital length of stay after injection of micro-fragmented autologous adipos... |
International Angiology : a Journal of the International Union of Angiology |
Gennai, Leone, Covic, Migliari, Lonardi, Silingardi |
2021-12-01 |
| 5950 |
Microfat - Orthopedics |
Regulatory and Ethical Aspects of Orthobiologic Therapies
|
November 30, 2022; Sage Journals/Murray, Biologics Association, The Orthopaedic Journal of Sports Medicine; Iain R. Murray, MFSEM, FRCS (Tr&Orth), PhD, Jorge Chahla, MD, PhD, Sarah J. Wordie, MBChB, Shane A. ... |
Orthobiologics show significant promise in improving outcomes for patients with a wide variety of musculoskeletal pathologies. There is considerable worldwide variation in the regulatory pathways that... |
Sage Journals/Murray, Biologics Association, The Orthopaedic Journal of Sports Medicine |
Iain R. Murray, MFSEM, FRCS (Tr&Orth), PhD, Jorge Chahla, MD, PhD, Sarah J. Wordie, MBChB, Shane A. Shapiro, MD, Nicolas S. Piuzzi, MD, Rachel M. Frank, MD, Joanne Halbrecht, MD, Kiyoshi Okada, MD, PhD, Norimasa Nakamura, MD, Bert Mandelbaum, MD, Jason L. Dragoo, MD |
2022-11-30 |
| 5975 |
Microfat |
Regenerative and Endoscopic Treatment of Complex Recurrent Fistula in Ano: When Technology Supports Clinical Treatment
|
November 2011; International Journal or Regenerative Medicine; Marco Di Monte, Giovanni Cestaro, Luca Regusci, Fabrizio Fasolini, and Ken Galetti |
MFAT injections are more effective in promoting tissue regeneration than simply “filling” the fistula tract and are common practice also in the treatment of Crohn’s Disease due to the immunomodu... |
International Journal or Regenerative Medicine |
Marco Di Monte, Giovanni Cestaro, Luca Regusci, Fabrizio Fasolini, and Ken Galetti |
2011-11-07 |
| 7340 |
Science/Research |
Arthroscopic Rotator Cuff Repair Augmentation With Autologous Microfragmented Lipoaspirate Tissue Is Safe and Effectivel...
|
August 22, 2022; The American Journal of Sports Medicine; Pietro S. Randelli, MD, Davide Cucch, MD, Chiara Fossati, PhD, Linda Boerci, MD, Elisabetta Nocerino... |
This prospective randomized controlled trial demonstrated that the intraoperative injection of autologous microfragmented adipose tissue is safe and effective in improving short-term clinical and func... |
The American Journal of Sports Medicine |
Pietro S. Randelli, MD, Davide Cucch, MD, Chiara Fossati, PhD, Linda Boerci, MD, Elisabetta Nocerino, MD, Federico Ambrogi, PhD, and Alessandra Menon, PhD |
2022-08-22 |
| 6050 |
Science/Research |
Microfragmented Adipose Tissue Versus Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Prospective Rando...
|
August 2022; The American Journal of Sports Medicine - Volume 50, Issue 11; Stefano Zaffagnini, MD, Prof., Luca Andriolo, MD, Angelo Boffa, MD, Alberto Poggi, MD, Annarita Cena... |
A single intra-articular injection of MF-AT was not superior to PRP, with comparable low numbers of failures and adverse events and without disease progression. No differences were found in clinical a... |
The American Journal of Sports Medicine - Volume 50, Issue 11 |
Stefano Zaffagnini, MD, Prof., Luca Andriolo, MD, Angelo Boffa, MD, Alberto Poggi, MD, Annarita Cenacchi, MD, Maurizio Busacca, MD, Elizaveta Kon, MD, Prof., Giuseppe Filardo, MD, PhD, MBA, Prof., and Alessandro Di Martino, MD |
2022-08-19 |
| 10000 |
Microfat - Aesthetics |
Lypogold Method. A Standardized Injection Technique Of Fat-Rich In Vascular Stromal Fraction For A Soft Face-Lift And Re...
|
February 01, 2023; Elite Aesthetics Institute; Guarino, Enrico MD |
Evaluate the use of a definite dosage of stable nanofat quantity injected with a standard quantity in the face ligaments for obtaining a lifting effect connected with the fat injected and a regenerati... |
Elite Aesthetics Institute |
Guarino, Enrico MD |
2023-02-01 |
| 8950 |
Microfat - Orthopedics |
An observational study evaluating the efficacy of microfragmented adipose tissue in the treatment of osteoarthritis
|
December 21, 2022; Regenerative Medicine, Vol. 18, No. 2; Frankie Fan, Robert A Grant, Jonathan P Whitehead, Alun Yewlett, & Paul Y F Lee |
A microfragmented adipose tissue injection to the shoulder or knee of osteoarthritis patients offers a safe and effective treatment in moderate-to-severe disease, with reduced efficacy at increased BM... |
Regenerative Medicine, Vol. 18, No. 2 |
Frankie Fan, Robert A Grant, Jonathan P Whitehead, Alun Yewlett, & Paul Y F Lee |
2022-12-21 |
| 6000 |
Science/Research |
Surgical implantation of human adipose derived stem cells attenuates experimentally induced hepatic fibrosis in rats
|
November 29, 2022; Molecular Medicine; Masateru Nomura, Joseph George, Chieko Hashizume, Takashi Saito, Yoshimichi Ueda, Yasuhito Ishigaki,... |
An evaluation of the effects of human adipose derived stem cells (hADSCs) to attenuate experimentally induced hepatic fibrosis and early cirrhosis in rats. |
Molecular Medicine |
Masateru Nomura, Joseph George, Chieko Hashizume, Takashi Saito, Yoshimichi Ueda, Yasuhito Ishigaki, Mutsumi Tsuchishima, Mikihiro Tsutsumi |
2022-11-29 |
| 7750 |
Microfat - Orthopedics |
Is intra-articular injection of autologous micro-fragmented adipose tissue effective in hip osteoarthritis? A three year...
|
October 28, 2022; International Orthopaedics; Simone Natali, Daniele Screpis, Michele Romeo, Stefano Magnanelli, Giuseppe Rovere, Amarossi Andrea,... |
To demonstrate how hip articular injections with autologous MFAT can have an impact on clinical outcomes. |
International Orthopaedics |
Simone Natali, Daniele Screpis, Michele Romeo, Stefano Magnanelli, Giuseppe Rovere, Amarossi Andrea, Lawrence Camarda, Claudio Zorzi |
2022-10-28 |
| 9100 |
Wound Healing |
Lipoaspirate Shows In Vitro Potential for Wound Healing
|
February 19, 2022; Pharmaceutics 2022, 14(2), 447; Chiara Ceresa, Alessia Borrone, Letizia Fracchia, Maurizio Rinaldi, Alice Marchetti, Carlo Tremolada... |
Lipoaspirate may be a promising approach in wound healing showing in vitro regenerative and antibacterial activities that could improve current therapeutic strategies. |
Pharmaceutics 2022, 14(2), 447 |
Chiara Ceresa, Alessia Borrone, Letizia Fracchia, Maurizio Rinaldi, Alice Marchetti, Carlo Tremolada, and Michela Bosetti |
2022-02-19 |
| 8500 |
Diseases |
Guided Lymphangiogenesis for the Treatment of Lymphedema: Preliminary Clinical Results
|
January 2022; Jointechlabs, Inc.; Catarina Hadamitzky, Tatiana S. Zaitseva, Nathan Katz, Claire P Edelstein, Manuel T. Escarraman, Dun... |
To address the limitations of current treatments for secondary lymphedema, a group developed an experimental surgical procedure based on Autologous Lymph Node Fragment (ALNF) transfer supplemented by ... |
Jointechlabs, Inc. |
Catarina Hadamitzky, Tatiana S. Zaitseva, Nathan Katz, Claire P Edelstein, Manuel T. Escarraman, Dung Nguyen, Michael V. Paukshto |
2022-01-01 |
| 9100 |
Wound Healing |
A Feasibility Study on 3D Bioprinting of Microfat Constructs Towards Wound Healing Applications
|
July 27, 2021; Frontiers in Bioengineering and Biotechnology; Schmitt, Trevor, Katz, Nathan, Kishore, Vipuil |
A chronic-wound-healing report on an innovative closed-loop fat processing system that can efficiently process lipoaspirates into microfat clusters comprising of highly viable regenerative cell popula... |
Frontiers in Bioengineering and Biotechnology |
Schmitt, Trevor, Katz, Nathan, Kishore, Vipuil |
2021-07-27 |
| 7800 |
Wound Healing |
The role of adjunct nanofibrillar collagen scaffold implantation in the surgical management of secondary lymphedema: Rev...
|
May 2021; Journal of Surgical Oncology; Danielle H. Rochlin, Suzanne Inchauste, Justin Zelones, Dung H. Nguyen |
Secondary lymphedema is a worldwide affliction that exacts a significant public health burden. This review examines the etiology, presentation, and management of secondary lymphedema. |
Journal of Surgical Oncology |
Danielle H. Rochlin, Suzanne Inchauste, Justin Zelones, Dung H. Nguyen |
2021-05-04 |
| 8600 |
Microfat - Orthopedics |
Short Review: Non-cultured Adipose-derived MSCs for Treatment of OA, Jointechlabs, Inc.
|
January 11, 2021; Jointechlabs, Inc.; Katz, Nathan, Phd |
A compendium of recent research links. |
Jointechlabs, Inc. |
Katz, Nathan, Phd |
2021-01-11 |
| 8700 |
Diseases |
Nanofibrillar Scaffold with Plated Adipose-Derived Stem Cells, Its Use for Lymphedema Treatment in Rats, and Path for Cl...
|
January 11, 2021; Jointechlabs, Inc.; Gloria Sue, Dung Nguyen, Dimitris Dionysiou, Tatiana Zaitseva, Cristhian Montenegro, Peter Tabada, P... |
To address the current deficit of sustainable lymphedema treatment, lymphatic regeneration guided by thread-like aligned nanofibrillar collagen scaffolds (BioBridge), which facilitate cell attachment,... |
Jointechlabs, Inc. |
Gloria Sue, Dung Nguyen, Dimitris Dionysiou, Tatiana Zaitseva, Cristhian Montenegro, Peter Tabada, Peter Deptula, Derrick Wan, Nathan Katz, Michael Paukshto, Stanley Rockson |
2021-01-11 |
| 8800 |
Microfat |
Comparison of Different Conditions for the Survival of Human Abdominal Fat in vitro
|
January 11, 2021; Jointechlabs, Inc.; Katz, N., Koukharenko, V. and Geldner, P. |
Testing the assumption that adding purified autologous adipose-derived mesenchymal stem cells (ADMSC) could improve the survival of fat transplants. |
Jointechlabs, Inc. |
Katz, N., Koukharenko, V. and Geldner, P. |
2021-01-11 |
| 8900 |
Microfat |
Combining Freshly Isolated Adipose-derived Cells With Regenogel-OSP
|
January 11, 2021; Jointechlabs, Inc.; Katz, Nathan, Phd, Yayun, Avner, MD PhD |
Testing the combination of a hyaluronic-acid – plasma cross-linked hydrogel with adipose-derived cell fraction. |
Jointechlabs, Inc. |
Katz, Nathan, Phd, Yayun, Avner, MD PhD |
2021-01-11 |
| 9000 |
Wound Healing |
3D Bioprinting of Autologous Adipose Tissue for Wound Healing
|
January 11, 2021; Jointechlabs, Inc.; Katz, Nathan PhD |
Stromal vascular fraction (SVF), which is isolated from fat, can be utilized to facilitate the healing of criotical skin wounds. |
Jointechlabs, Inc. |
Katz, Nathan PhD |
2021-01-11 |
| 7900 |
Microfat - Orthopedics |
Chemical Profile and Clincal Efficacy of Adipose-Derived Proceedings Mesenchymal Stromal Cell Therapy in the Treatment o...
|
June 23, 2020; Biologic Orthopedic Journal, Vol 2(1):e13–e24; Haber, J., Hogaboom, N., Malanga, G. |
This review article serves to present the following objectives: (1) to summarize the techniques used to harvest AD-MSCs, via micro-fragmentation and enzymatic processing. |
Biologic Orthopedic Journal, Vol 2(1):e13–e24 |
Haber, J., Hogaboom, N., Malanga, G. |
2020-06-23 |
| 7900 |
Microfat - Orthopedics |
Early results of intra-articular micro-fragmented lipoaspirate treatment in patients with late stages knee osteoarthriti...
|
June 13, 2019; Croat Medical Journal; Damir Hudetz, Igor Borić, Eduard Rod, Željko Jeleč, Barbara Kunovac, Ozren Polašek, Trpimir Vrdo... |
To analyze clinical and functional effects of intra-articular injection of autologous micro-fragmented lipoaspirate (MLA) in patients with late stage knee osteoarthritis (KOA). Secondary aims included... |
Croat Medical Journal |
Damir Hudetz, Igor Borić, Eduard Rod, Željko Jeleč, Barbara Kunovac, Ozren Polašek, Trpimir Vrdoljak, Mihovil Plečko, Andrea Skelin, Denis Polančec, Lucija Zenić, Dragan Primorac |
2019-06-13 |