Regenerative Medicine Research Library
Industry news and research relevant to medical professionals and the regenerative medicine field.
Topic | Title | Date/Source/Authors | Summary |
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Microfat | Corticosteroids, hyaluronic acid, platelet-rich plasma, and cell-based therapies for knee osteoarthritis – literat... | March 03, 2025; Expert Opinion on Biological Therapy; Alessandro Bensa, Luca Bianco Prevot, Giacomo Moraca, Alessandro Sangiorgio, Angelo Boffa, Giuseppe ... | The aim of this systematic review was to quantify the data available on corticosteroids (CS), hyaluronic acid, (HA), platelet-rich plasma (PRP), and cell-based therapies for knee osteoarthritis (OA) t... |
Science/Research | Adipose-mesenchymal stem cells enhance the formation of auricular cartilage in vitro and in vivo | April 30, 2025; Stem Cells Translation Medicine; Dominika Zielinska, Katarzyna Micka-Michalak, Hyrije Ademi, Philip Fisch, Roland Boeni, Thomas Linde... | The authors demonstrate the successful use of an hASC-chondrocyte co-culture technique for auricular cartilage tissue engineering in 3D collagen-I bioink. This co-culture approach omits the major draw... |
Microfat | The Regenerative Marriage Between High-Density Platelet-Rich Plasma and Adipose Tissue | February 27, 2025; International Journal of Molecular Sciences; Peter A. Everts, Luga Podesta, José Fabio Lana, George Shapiro, Rafael Barnabé Domingues, Andre va... | An exploration of a synergistic effect, where the HD-PRP constituents enhance the regenerative potential of t-SVF and its adipose-derived mesenchymal stem cells (AD-MSCs) and pericytes, leading to imp... |
Microfat - Orthopedics | Microfragmented Adipose Tissue Injection Reduced Pain Compared With a Saline Control Among Patients With Symptomatic Ost... | February 2025; The Journal of Arthroscopic and Related Surgery; Dustin L. Richter M.D., Joshua L. Harrison M.D., Lauren Faber M.D., Samuel Schrader M.D., Yiliang Zh... | To evaluate the effectiveness of microfragmented adipose tissue (MFAT) for pain relief and improved joint functionality in osteoarthritis (OA) of the knee in a randomized controlled clinical trial wit... |
Microfat - Orthopedics | Autologous Stromal Vascular Fraction and Microfragmented Adipose Tissue for Musculoskeletal Disorders: A Narrative Revie... | July 09, 2024; Examines in Physical Medicine & Rehabilitation (EPMR); Nathan Katz, Nishit Pancholi, Michelle Katz, and Mitchell Sheinkop | A review article discussing the use of Autologous Stromal Vascular Fraction (SVF) and Microfragmented Adipose Tissue (MFAT) for treating musculoskeletal disorders. |
Microfat - Orthopedics | Adipose Cellular Injection in the Treatment of An Intrasubstance Achilles Tendon Defect: A Case Report | September 06, 2022; Regenerative Medicine; Anthony M Iuso, Deborah Pacik, Joshua Martin, Devin Oakes, Gerard A Malanga | This case highlights the potential microfragmented adipose tissue has as a regenerative treatment modality for the management of partial Achilles tendon tears. |
Microfat - Orthopedics | Infiltration of micro-fragmented adipose tissue under local anesthesia for knee osteoarthritis treatment is a safe proce... | December 03, 2024; Clinics (Sao Paulo); Bruno Butturi Varone, Daniel Peixoto Leal, Daniel Duarte Perini, Vitor Penteado Figueiredo Pagotto, ... | The purpose of this study is to evaluate the safety of adipose tissue harvesting and mFAT injection under local anesthesia. |
Microfat - Orthopedics | Micro-fragmented adipose tissue (mFAT) associated with arthroscopic debridement provides functional improvement in knee ... | August 30, 2022; Knee Surgery, Sports Traumatology, Arthroscopy; Michele Ulivi, Valentina Meroni, Marco Viganò, Alessandra Colombini, Michele D. M. Lombardo, Nicol�... | The purpose of this prospective, randomized controlled clinical trial was to evaluate the effectiveness of mFAT applied in association with arthroscopic debridement (AD) for the treatment of knee OA, ... |
Microfat - Orthopedics | Microfragmented Adipose Tissue Associated With Collagen Membrane in the Treatment of Focal Knee Cartilage Defect | October 2024; Arthroscopy Techniques; Daniel Peixoto Leal M.D, Henrique Fuller M.D, Bruno Butturi Varone M.D, Andre Giardino Moreira da Si... | This article presents a surgical technique for the treatment of focal chondral lesions using a collagen membrane associated with microfragmented adipose tissue graft. |
Microfat - Orthopedics | Should I add orthobiologics to my knee osteotomy practice? A systematic review | June 06, 2024; Journal of Isakos; Amit Meenaa, Riccardo D’Ambrosib, Luca Farinellid, Norimasa Nakamurag, Matthieu Ollivierh, Sachin ... | This review presents recent evidence regarding using orthobiologics for knee osteoarthritis. The results of this study may guide surgeons to improve their clinical results and determine whether or not... |
Microfat - Orthopedics | Intra-articular injection of bone marrow aspirate concentrate (BMAC) or adipose-derived stem cells (ADSCs) for knee oste... | May 11, 2023; Journal of Orthopaedic Surgery and Research; Andrea Pintore, Donato Notarfrancesco, Arnaldo Zara, Antonio Oliviero, Filippo Migliorini, Francesco... | We determined whether autologous mesenchymal stem cells (MSCs) injections provide clinical and functional improvements in knee osteoarthritis (KOA) patients, and whether the results differ between aut... |
Microfat - Orthopedics | Autologous micro-fragmented adipose tissue injection provides significant and prolonged clinical improvement in patients... | November 16, 2023; The Journal of Experimental Orthopaedics; Arcangelo Russo, Gabriele Cortina, Vincenzo Condello, Marco Collarile, Roberto Orlandi, Riccardo Gia... | This study aims to demonstrate the benefits of autologous micro-fragmented adipose tissue (MAT) injection in the conservative treatment of knee osteoarthritis and whether any variables may affect th... |
Microfat - Orthopedics | Efficacy of stromal vascular fraction for knee osteoarthritis: A prospective, single-centre, non-randomized study with 2... | May 18, 2024; World Journal of Orthopedics; Madhan Jeyaraman, Naveen Jeyaraman, Tarun Jayakumar, Swaminathan Ramasubramanian, Rajni Ranjan, Saur... | A very recent study comparing the efficacy of intra-articular SVF with corticosteroid (ICS) injections in patients with primary knee OA. |
Microfat - Orthopedics | The outcomes of Treating Shoulder Degenerative Joint Disease (DJD) and Related Rotator Cuff Tears with Autologous Micro ... | May 22, 2024; Jointechlabs, Inc.; Sheinkop M, DeMers A, Ferrell J, Mahadevan S, and Katz N | A prospective, non-randomized, single-arm, clinical study examining the safety and efficacy of autologous MFAT generated by a MiniTC device for the management of pain and function in the shoulder join... |
Microfat - Orthopedics | Microfragmented Adipose Tissue Injection Reduced Pain Compared With a Saline Control Among Patients With Symptomatic Ost... | September 05, 2024; Arthroscopy: The Journal of Arthroscopic and Related Surgery; Dustin L. Richter, M.D, Joshua L. Harrison, M.D., Lauren Faber, M.D., Samuel Schrader, M.D., Yilia... | To evaluate the effectiveness of microfragmented adipose tissue (MFAT) for pain relief and improved joint functionality in osteoarthritis (OA) of the knee in a randomized controlled clinical trial wit... |
Microfat - Orthopedics | Microfragmented Adipose Tissue Is Equivalent to Platelet-Rich Plasma for Knee Osteoarthritis at 12 Months Posttreatment:... | March 18, 2024; Orthopaedic Journal of Sports Medicine; Michael Baria, Tyler Barker, Sushmitha Durgam, Angela Pedroza, David Flanigan, Liuqing Jia, Christop... | To perform a comparison of commercially available MFAT and PRP systems for treatment of knee OA. |
Microfat - Orthopedics | Clinical Evaluation of Safety and Efficacy of a Central Current Good Manufacturing Practices Laboratory Produced Autolog... | April 03, 2024; Stem Cells and Development; Christopher J Rogers, Robert Harman, Mitchell B Sheinkop, Peter Hanson, Mary A Ambach, Tal David, R... | A single-arm, open-label, multisite, FDA approved clinical study in Kellgren-Lawrence severity grade 2-4 KOA patients. The cellular product was manufactured from patient-specific lipoaspirate in a cen... |
Wound Healing | 3D Bioprinting of Autologous Adipose Tissue for Wound Healing | January 11, 2021; Jointechlabs, Inc.; Katz, Nathan PhD | Stromal vascular fraction (SVF), which is isolated from fat, can be utilized to facilitate the healing of critical skin wounds. |
Microfat | Characterization of Microfragmented Adipose Tissue Architecture, Mesenchymal Stromal Cell Content and Release of Paracri... | April 15, 2022; Journal of Clinical Medicine; Enrico Ragni, Marco Viganò, Enrica Torretta, Carlotta Perucca Orfei, Alessandra Colombini, Carlo Tr... | The purpose of this study was to first characterize both structure and cell content of unprocessed lipoaspirate (LA) and µFAT, and further identify and frame the array of signaling factors in the con... |
Microfat - Orthopedics | Autologous microfragmented adipose tissue treatment of knee osteoarthritis demonstrates effectiveness in 68% of patients... | January 11, 2024; Archives of Orthopaedic and Trauma Surgery; Francesco Onorato, Massimiliano Rucci, Mattia Alessio-Mazzola, Alessandro Bistolfi, Carlotta Castagn... | The aim of this study was to evaluate the medium-term effectiveness and safety of Microfragmented Autologous Fat Tissue (MFAT) injection treatment at 4-year follow-up. |
Microfat - Aesthetics | Lypogold Method. A Standardized Injection Technique Of Fat-Rich In Vascular Stromal Fraction For A Soft Face-Lift And Re... | February 01, 2023; Elite Aesthetics Institute; Guarino, Enrico MD | Evaluate the use of a definite dosage of stable nanofat quantity injected with a standard quantity in the face ligaments for obtaining a lifting effect connected with the fat injected and a regenerati... |
Microfat - Aesthetics | Regenerative medicine in the treatment of specific dermatologic disorders: a systematic review of randomized controlled ... | June 18, 2024; Stem Cell Research & Therapy; Alireza Jafarzadeh, Arash Pour Mohammad, Haniyeh Keramati1, Roya Zeinali, Mina Khosravi, and Azadeh ... | A review of randomized controlled clinical trials (RCTs) studying various types of regenerative medicine methods in treating specific dermatologic diseases. |
Microfat - Orthopedics | Microfragmented Adipose Tissue Injection Reduced Pain Compared With a Saline Control Among Patients With Symptomatic Ost... | September 05, 2024; The Journal of Arthroscopy and Related Surgery; Dustin L. Richter M.D., Joshua L. Harrison M.D., Lauren Faber M.D., Samuel Schrader M.D., Yiliang Z... | A study to evaluate the effectiveness of microfragmented adipose tissue (MFAT) for pain relief and improved joint functionality in osteoarthritis (OA) of the knee in a randomized controlled clinical t... |
Wound Healing | Lipoaspirate Shows In Vitro Potential for Wound Healing | February 19, 2022; Pharmaceutics 2022, 14(2), 447; Chiara Ceresa, Alessia Borrone, Letizia Fracchia, Maurizio Rinaldi, Alice Marchetti, Carlo Tremolada... | Lipoaspirate may be a promising approach in wound healing showing in vitro regenerative and antibacterial activities that could improve current therapeutic strategies. |
Wound Healing | A Feasibility Study on 3D Bioprinting of Microfat Constructs Towards Wound Healing Applications | July 27, 2021; Frontiers in Bioengineering and Biotechnology; Schmitt, Trevor, Katz, Nathan, Kishore, Vipuil | A chronic-wound-healing report on an innovative closed-loop fat processing system that can efficiently process lipoaspirates into microfat clusters comprising of highly viable regenerative cell popula... |
Microfat - Orthopedics | Cell-Based Therapies for Rotator Cuff Injuries: An Updated Review of the Literature | March 08, 2024; International Journal of Molecular Sciences; Nicholas Hooper, Anuj Marathe, Nitin B. Jain, and Prathap Jayaram | This review focuses on non-surgical treatment options for rotator cuff injuries and highlights the potential of mesenchymal stem cells (MSCs) as a potential regenerative approach. |
Microfat - Orthopedics | An observational study evaluating the efficacy of microfragmented adipose tissue in the treatment of osteoarthritis | December 21, 2022; Regenerative Medicine, Vol. 18, No. 2; Frankie Fan, Robert A Grant, Jonathan P Whitehead, Alun Yewlett, & Paul Y F Lee | A microfragmented adipose tissue injection to the shoulder or knee of osteoarthritis patients offers a safe and effective treatment in moderate-to-severe disease, with reduced efficacy at increased BM... |
Microfat - Orthopedics | Efficacy and Long-Term Outcomes of Intra-Articular Autologous Micro-Fragmented Adipose Tissue in Individuals with Glenoh... | August 26, 2023; Journal of Personalized Medicine; Simone Natali, Daniele Screpis, Edoardo Patania, Luca De Berardinis, Andrea Benoni, Gianluca Piovan,... | The aim of this retrospective study was to report the safety and clinical outcomes of intra-articular injection of ADMSCs in patients with GOA over 36-months. |
Microfat - Aesthetics | Protein Profiling of Mechanically Processed Lipoaspirates: Discovering Wound Healing and Antifibrotic Biomarkers in Nano... | June 06, 2022; Plastic and Reconstructive Surgery; Nadia Sanchez-Macedo, Ph.D., Michelle McLuckie, Ph.D.,Lisanne Grünherz, M.D.,and Nicole Lindenblatt... | This study shows that the effects of microfat and nanofat treatment are based on up-regulated inflammation, antimicrobial, and wound healing pathways. Mechanical emulsification does not alter the conc... |
Microfat | Combining Freshly Isolated Adipose-derived Cells With Regenogel-OSP | January 11, 2021; Jointechlabs, Inc.; Katz, Nathan, Phd, Yayun, Avner, MD PhD | Testing the combination of a hyaluronic-acid – plasma cross-linked hydrogel with adipose-derived cell fraction. |
Microfat | Comparison of Different Conditions for the Survival of Human Abdominal Fat in vitro | January 11, 2021; Jointechlabs, Inc.; Katz, N., Koukharenko, V. and Geldner, P. | Testing the assumption that adding purified autologous adipose-derived mesenchymal stem cells (ADMSC) could improve the survival of fat transplants. |
Diseases | Nanofibrillar Scaffold with Plated Adipose-Derived Stem Cells, Its Use for Lymphedema Treatment in Rats, and Path for Cl... | January 11, 2021; Jointechlabs, Inc.; Gloria Sue, Dung Nguyen, Dimitris Dionysiou, Tatiana Zaitseva, Cristhian Montenegro, Peter Tabada, P... | To address the current deficit of sustainable lymphedema treatment, lymphatic regeneration guided by thread-like aligned nanofibrillar collagen scaffolds (BioBridge), which facilitate cell attachment,... |
Microfat - Orthopedics | Short Review: Non-cultured Adipose-derived MSCs for Treatment of OA, Jointechlabs, Inc. | January 11, 2021; Jointechlabs, Inc.; Katz, Nathan, Phd | A compendium of recent research links. |
Diseases | Guided Lymphangiogenesis for the Treatment of Lymphedema: Preliminary Clinical Results | January 2022; Jointechlabs, Inc.; Catarina Hadamitzky, Tatiana S. Zaitseva, Nathan Katz, Claire P Edelstein, Manuel T. Escarraman, Dun... | To address the limitations of current treatments for secondary lymphedema, a group developed an experimental surgical procedure based on Autologous Lymph Node Fragment (ALNF) transfer supplemented by ... |
Microfat - Orthopedics | Microfragmented Adipose Tissue Injection (MFAT) May Be a Solution to the Rationing of Total Knee Replacement: A Prospect... | June 09, 2021; Stem Cells International; Nima Heidari, Tiffanie-Marie Borg, Stefano Olgiati, Mark Slevin, Alessandro Danovi, Brady Fish, Adri... | Referral for knee replacement surgery is often guided by the patient’s Oxford Knee Score. Recent therapies including treatment with MFAT have emerged as alternatives to relieve pain and improve ... |
Microfat - Orthopedics | Microfragmented Adipose Tissue in the Treatment of a Full-Thickness Supraspinatus Tear: A Case Report | September 20, 2023; Regenerative Medicine; John L. Ferrell, Alanna Dodson, Joshua Martin | This case demonstrates the efficacy of microfragmented adipose tissue as a relatively novel approach to treating non-retracted, full-thickness rotator cuff tears. |
Wound Healing | Microfat exerts an anti-fibrotic effect on human hypertrophic scar via fetuin-A/ETV4 axis | March 31, 2023; Journal of Translational Medicine; Qian Yu, Qiang Dai, Zonglin Huang, Chen Li, Li Yan, Xin Fu, Qian Wang, Yi Zhang, Lei Cai, Zhigang Ya... | Hypertrophic scar is a fibrotic disease following wound healing and is characterized by excessive extracellular matrix deposition. Autologous microfat grafting proves an effective strategy for the tre... |
Microfat - Orthopedics | Good mid-term outcomes after adipose-derived culture-expanded mesenchymal stem cells implantation in knee focal cartilag... | September 06, 2019; Knee Surgery, Sports Traumatology, Arthroscopy; Theofylaktos Kyriakidis, Michael Iosifidis, Efstathios Michalopoulos, Ioannes Melas, Catherine Stavr... | The purpose of the present study was to investigate the mid-term outcomes of a single-stage cell-based procedure in patients with knee focal symptomatic cartilage defects using matrix-induced culture-... |
Science/Research | Adipose tissue and the vascularization of biomaterials: Stem cells, microvascular fragments and nanofat-a review | June 02, 2020; Cytotherapy; Pranitha Kamat, Florian S Frueh, Michelle McLuckie, Nadia Sanchez-Macedo, Petra Wolint, Nicole Linde... | In this narrative review, derivatives of adipose tissue and the vascularization of biomaterials are addressed in a comprehensive approach, including several sizes of derivatives, such as whole fat fla... |
Microfat | Treatment of Fistulizing Perianal Crohn’s Disease by Autologous Microfat Enriched With Adipose-Derived Regenerativ... | November 13, 2021; Inflammatory Bowel Diseases; Karam Matlub Sørensen, Charlotte Harken Jensen, Søren Paludan Sheikh, Niels Qvist, Jens Ahm Søre... | The aim of the present study was to evaluate the outcome and safety of treating fistulizing pCD with autologous fat graft enriched with ADRC. The primary outcome was the healing rate defined as absenc... |
Microfat - Orthopedics | Functional Outcomes Following Microfragmented Adipose Tissue Versus Bone Marrow Aspirate Concentrate Injections for Symp... | November 01, 2019; Stem Cells Translational Medicine; Kenneth Mautner, Robert Bowers, Kirk Easley, Zachary Fausel, Ryan Robinson | This study aimed to determine whether autologous orthobiologic tissue source affects pain and functional outcomes in patients with symptomatic knee osteoarthritis (OA) who received microfragmented adi... |
Microfat - Orthopedics | Intra-Articular Injection of Autologous Microfat and Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Dou... | April 19, 2021; Arthroscopy Techniques - VOLUME 6, ISSUE 5, E1761-E1766; Marie Laure Louis, Robinson Gravier Dumonceau, Elisabeth Jouve, Michel Cohen, Rym Djouri, Nathalie R... | To compare a single abdominal microfat (MF) injection mixed or not with platelet-rich plasma (PRP) Low Dose (LD) or High Dose (HD) in order to improve MRI parameters, alleviate pain and enhance functi... |
Microfat | Three-year outcome of local injection of autologous stromal vascular fraction cells and microfat in refractory perianal ... | February 09, 2022; Stem Cell Research and Therapy; Lucas Guillo, Fanny Grimaud, Fanny Houser,Caroline Prost, Elisabeth Jouve, Cécile Philandrianos, Ma... | In a pilot study, including patients with refractory complex perianal fistulas, autologous adipose-derived stromal vascular fraction (ADSVF) combined with microfat achieved combined remission in 60% o... |
Microfat - Orthopedics | Intra Articular Injection of Autologous Microfat and Platelets-Rich Plasma in the Treatment of Wrist Osteoarthritis: A P... | September 29, 2022; Journal of Clinical Medicine; Alice Mayoly, Marie Witters, Elisabeth Jouve, Cécilia Bec, Aurélie Iniesta, Najib Kachouh, Julie ... | Emergence of biotherapies based on adipose derived stem cells (ADSC) offers promising treatments for chondral degenerative diseases. Microfat (MF) and platelets-rich plasma (PRP) mixture, rich in grow... |
Microfat - Orthopedics | Subchondral versus intra-articular orthobiologic injections for the treatment of knee osteoarthritis: a review | April 12, 2022; Regenerative Medicine; James E Gardner, Christopher W Williams, Robert L Bowers | This review highlights the rationale and current evidence for intra-articular and subchondral bone injections of orthobiologics for the treatment of OA. |
Microfat - Orthopedics | Stromal Vascular Fraction for Knee Osteoarthritis – An Update | April 05, 2022; Journal of Stem Cells and Regenerative Medicine; José Fábio Santos Duarte Lana, Anna Vitória Santos Duarte Lana, Lucas Furtado da Fonseca, Marcelo... | Stromal vascular fraction obtained from processed adipose tissue may be presented as an excellent orthobiologic tool for the treatment of many complicated and impactful musculoskeletal disorders, such... |
Microfat - Orthopedics | Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA... | September 14, 2022; Knee Surgery, Sports Traumatology, Arthroscopy; Carlotta Perucca Orfei, Angelo Boffa,Yosef Sourugeon, Lior Laver, Jérémy Magalon, Mikel Sánchez, ... | The aim of this systematic review was to determine if adipose tissue-derived cell-based injectable therapies can induce disease-modifying effects in joints affected by osteoarthritis (OA). |
Microfat - Orthopedics | Autologous Microfragmented Adipose Tissue for the Treatment of Knee Osteoarthritis: Real-World Data at Two Years Follow-... | February 25, 2022; Journal of Clinical Medicine; Daniele Screpis, Simone Natali, Luca Farinelli, Gianluca Piovan, Venanzio Iacono, Laura de Girolamo,... | The purpose of the present study was to assess, prospectively, the safety, clinical effectiveness, and feasibility of a single intra-articular injection of microfragmented adipose tissue in different ... |
Microfat - Aesthetics | A Novel Fat Making Strategy With Adipose-Derived Progenitor Cell-Enriched Fat Improves Fat Graft Survival | May 08, 2021; Aesthetic Surgery Journal; Pengju Fan, Man Fang, ingjing Li, Mario G Solari, Dingyu Wu, Wuyuan Tan, Yongjie Wang, Xinghua Yang,... | A low survival rate is one of the main challenges in fat grafting. This study aimed to evaluate whether microfat obtained by a novel strategy promoted the survival and retention of fat grafts. |
Microfat - Orthopedics | Chemical Profile and Clincal Efficacy of Adipose-Derived Proceedings Mesenchymal Stromal Cell Therapy in the Treatment o... | June 23, 2020; Biologic Orthopedic Journal, Vol 2(1):e13–e24; Haber, J., Hogaboom, N., Malanga, G. | This review article serves to present the following objectives: (1) to summarize the techniques used to harvest AD-MSCs, via micro-fragmentation and enzymatic processing. |