{"id":2332,"date":"2025-06-08T08:07:07","date_gmt":"2025-06-08T15:07:07","guid":{"rendered":"https:\/\/jointechlabstg.wpengine.com\/?page_id=2332"},"modified":"2025-06-08T20:43:03","modified_gmt":"2025-06-09T03:43:03","slug":"clinical-studies-on-microfragmented-adipose-tissue-mfat-in-stage-3-and-4-osteoarthritis","status":"publish","type":"page","link":"https:\/\/jointechlabs.com\/de\/clinical-studies-on-microfragmented-adipose-tissue-mfat-in-stage-3-and-4-osteoarthritis\/","title":{"rendered":"Klinische Studien \u00fcber mikrofragmentiertes Fettgewebe (MFAT) bei Osteoarthritis im Stadium 3 und 4"},"content":{"rendered":"<h4 class=\"wp-block-heading\" id=\"h-1-randomized-controlled-trial-arthroscopic-debridement-mfat\">1. Randomisierte, kontrollierte Studie (arthroskopisches Debridement \u00b1 MFAT)<\/h4>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Titel: <\/strong>Mikrofragmentiertes Fettgewebe (mFAT) in Verbindung mit arthroskopischem D\u00e9bridement f\u00fchrt zu einer funktionellen Verbesserung bei Kniearthrose: eine randomisierte kontrollierte Studie<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Zeitschrift:<\/strong> Internationale Orthop\u00e4die<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Entwurf:<\/strong> 78 Patienten mit Knie-OA&nbsp;<strong>Klasse 3-4<\/strong>&nbsp;randomisiert auf arthroskopisches Debridement (AD) allein oder AD + MFAT.<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Nachbereitung:<\/strong> 6 Monate und ~26 Monate.<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Ergebnisse:<\/strong>  Nach 6 Monaten wies die Gruppe AD + MFAT eine gr\u00f6\u00dfere Verbesserung auf:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>KOOS-PS (+24,4 gegen\u00fcber +11,7, p = 0,024).<\/li>\n\n\n\n<li>KSS (+24,8 gegen\u00fcber +14,9, p = 0,046).<\/li>\n<\/ul>\n\n\n\n<p class=\"SmallBottomMargin\">Mit ~24 Monaten:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>KOOS-PS Funktion beg\u00fcnstigte die MFAT-Gruppe (p = 0,012).<\/li>\n\n\n\n<li>Das MRT-T2-Mapping zeigte eine bessere Knorpelqualit\u00e4t in der MFAT-Gruppe (p &lt; 0,001).<\/li>\n<\/ul>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Schlussfolgerung:<\/strong> MFAT in Kombination mit einem arthroskopischen D\u00e9bridement verbesserte die Funktionswerte und die Knorpeldarstellung gegen\u00fcber dem D\u00e9bridement allein.<\/p>\n\n\n\n<p><strong>Link:<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36040510\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36040510<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-2-prospective-cohort-study\">2. Prospektive Kohortenstudie<\/h4>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Titel:<\/strong> Fr\u00fche Ergebnisse der intraartikul\u00e4ren Behandlung mit mikrofragmentierten Lipoaspiraten bei Patienten mit Kniearthrose im Sp\u00e4tstadium: eine prospektive Studie<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Zeitschrift:<\/strong> Kroatische Medizinische Zeitschrift (2019)<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Entwurf:<\/strong> 20 Patienten (<strong>4 Grad III, 16 Grad IV)<\/strong>&nbsp;mit intraartikul\u00e4rem MFAT behandelt.<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>12-monatige Nachuntersuchung:<\/strong><\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>85% (17\/20) vermeidet Knieersatz.<\/strong><\/p>\n\n\n\n<p class=\"SmallBottomMargin\">Die VAS verbesserte sich um ~54-82%; WOMAC und KOOS zeigten ~40-176% Verbesserung (p &lt; 0,001).<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Schlussfolgerung:<\/strong> MFAT f\u00fchrte zu einer starken klinischen Verbesserung und einer hohen Rate an vermiedenen Operationen.<\/p>\n\n\n\n<p><strong>Link<\/strong>: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31187950\">https:\/\/pubm<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31187950\" target=\"_blank\" rel=\"noreferrer noopener\">ed.ncbi.nlm.nih.gov\/31187950<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-3-open-label-cohort-with-dgemric-mri-evaluation\">3. Offene Kohorte mit dGEMRIC-MRT-Auswertung<\/h4>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Titel:<\/strong> Die Wirkung der intraartikul\u00e4ren Injektion von autologem mikrofragmentiertem Fettgewebe auf die Proteoglykan-Synthese bei Patienten mit Kniearthrose<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Zeitschrift:<\/strong> Gene (2017)<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Entwurf:<\/strong> Einmalige MFAT-Injektion bei Patienten mit Grad&nbsp;<strong>II-IV OA.<\/strong><\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Ergebnisse:<\/strong><\/p>\n\n\n\n<p class=\"SmallBottomMargin\">Die MRT mit dGEMRIC zeigte Hinweise auf eine Proteoglykansynthese.<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Schlussfolgerung:<\/strong> MFAT scheint sicher zu sein und kann den Erhalt der Knorpelmatrix unterst\u00fctzen.<\/p>\n\n\n\n<p><strong>Link<\/strong>: <a href=\"https:\/\/www.mdpi.com\/2073-4425\/8\/10\/270\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.mdpi.com\/2073-4425\/8\/10\/270<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-4-medium-term-prospective-trial-4-years\">4. Mittelfristige prospektive Studie (~4 Jahre)<\/h4>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Titel:<\/strong> Autologe Behandlung von Kniearthrose mit mikrofragmentiertem Fettgewebe erweist sich bei 68% der Patienten nach 4 Jahren als wirksam<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Zeitschrift:<\/strong> Archiv f\u00fcr Orthop\u00e4die und Unfallchirurgie (2023)<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Entwurf:<\/strong> 46 Patienten mit diagnostischer Arthroskopie + MFAT-Injektion.<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Ergebnisse:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Lysholm-Score: 61,7 \u2192 79,5 (p &lt; 0,001)<\/li>\n\n\n\n<li>WOMAC: 66,5 \u2192 82,8 (p &lt; 0,001)<\/li>\n\n\n\n<li class=\"SmallBottomMargin\">VAS: 6,3 \u2192 3,5 (p &lt; 0,001)<\/li>\n<\/ul>\n\n\n\n<p class=\"SmallBottomMargin\">33% erforderte zus\u00e4tzliche Ma\u00dfnahmen&nbsp;<strong>\u00fcber 4 Jahre.<\/strong><\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Schlussfolgerung:<\/strong> Dauerhafte Linderung von Symptomen bei der Mehrheit der Patienten.<\/p>\n\n\n\n<p><strong>Link<\/strong>: <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00402-023-05143-y\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/link.springer.com\/article\/10.1007\/s00402-023-05143-y<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-5-systematic-review-2024-jointechlabs-study\">5. Systematische \u00dcberpr\u00fcfung (2024) - Jointechlabs-Studie<\/h4>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Titel: <\/strong>Autologe stromale Gef\u00e4\u00dffraktion und mikrofragmentiertes Fettgewebe bei Muskel-Skelett-Erkrankungen: Ein narrativer \u00dcberblick<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Zeitschrift:<\/strong> Arthroskopie, Sportmedizin und Rehabilitation<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Schlussfolgerungen:<\/strong><\/p>\n\n\n\n<p class=\"SmallBottomMargin\">MFAT f\u00fchrt zu einer deutlichen Schmerzlinderung und Funktionsverbesserung.<\/p>\n\n\n\n<p class=\"SmallBottomMargin\"><strong>Wichtige Einblicke:<\/strong><\/p>\n\n\n\n<p class=\"SmallBottomMargin\">Wirksamkeit: MFAT verbessert den Schmerz (VAS), die Funktion (WOMAC, KOOS) und sch\u00fctzt den Knorpel.<\/p>\n\n\n\n<p class=\"SmallBottomMargin\">Schweregrad: Selbst Patienten mit fortgeschrittener OA (Stadium 3-4) profitieren erheblich.<\/p>\n\n\n\n<p class=\"SmallBottomMargin\">Sicherheit: In allen Studien wurden nur wenige unerw\u00fcnschte Ereignisse gemeldet.<\/p>\n\n\n\n<p><strong>Link:<\/strong> <a href=\"https:\/\/crimsonpublishers.com\/epmr\/fulltext\/EPMR.000602.php\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/crimsonpublishers.com\/epmr\/fulltext\/EPMR.000602.php<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>Schlussfolgerung:<\/strong> MFAT zeigt ein gro\u00dfes Potenzial bei der Behandlung von Kniearthrose im Stadium 3-4, insbesondere bei der Verbesserung der Funktion und der Verz\u00f6gerung des Gelenkersatzes.&nbsp;<\/p>\n\n\n<input type=\"button\" value=\"Zur\u00fcck\" class=\"alg_back_button_input my-back-button\" style=\"\" onclick=\"window.history.back()\" \/>","protected":false},"excerpt":{"rendered":"<p>1. Randomized Controlled Trial (Arthroscopic Debridement \u00b1 MFAT) Title: Micro-fragmented adipose tissue (mFAT) associated with arthroscopic debridement provides functional improvement in knee osteoarthritis: a randomized controlled trial Journal: International Orthopaedics Design: 78 patients with knee OA&nbsp;grade 3\u20134&nbsp;randomized to arthroscopic debridement (AD) alone or AD + MFAT. Follow-up: 6 months and ~26 months. Outcomes: At 6 [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"footnotes":""},"class_list":["post-2332","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Clinical Studies on Microfragmented Adipose Tissue (MFAT) in Stage 3 and 4 Osteoarthritis - Jointechlabs, Inc<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jointechlabs.com\/de\/clinical-studies-on-microfragmented-adipose-tissue-mfat-in-stage-3-and-4-osteoarthritis\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clinical Studies on Microfragmented Adipose Tissue (MFAT) in Stage 3 and 4 Osteoarthritis\" \/>\n<meta property=\"og:description\" content=\"1. Randomized Controlled Trial (Arthroscopic Debridement \u00b1 MFAT) Title: Micro-fragmented adipose tissue (mFAT) associated with arthroscopic debridement provides functional improvement in knee osteoarthritis: a randomized controlled trial Journal: International Orthopaedics Design: 78 patients with knee OA&nbsp;grade 3\u20134&nbsp;randomized to arthroscopic debridement (AD) alone or AD + MFAT. Follow-up: 6 months and ~26 months. 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Randomized Controlled Trial (Arthroscopic Debridement \u00b1 MFAT) Title: Micro-fragmented adipose tissue (mFAT) associated with arthroscopic debridement provides functional improvement in knee osteoarthritis: a randomized controlled trial Journal: International Orthopaedics Design: 78 patients with knee OA&nbsp;grade 3\u20134&nbsp;randomized to arthroscopic debridement (AD) alone or AD + MFAT. Follow-up: 6 months and ~26 months. 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